Hi. I'm in the process of building my system (not the first one), can share some of my thoughts.
As for me, the rear speakers are totally useless, especially if you think of them as thin membranes dividing two closed volumes of air, in one of which you have your hard-kicking subwoofer... See where i'm going? I just removed my rear speakers and have no regrets ) Imho, it is better to focus on the front speakers.
Front speakers are 5.25" which isn't great. Even worse - speakers bolted to the plastic door cover, not the door sheet metal. I have really good speakers (Focal 130AS), they sound amazing, but, to my taste, they aren't loud enough. Not to say they aren't loud - just not loud enough, sometimes. I haven't decided yet what to do with that. One way is to choose louder speakers which almost definately will sound worse than my Focals. Probably I should find a way to bolt speakers to the metal, that would improve number of things including (hopefully) loudness. The other way, radical one, is to build custom "podiums" and fit some good 6.5" in there.
Now subwoofer. I have 400 Watt RMS 12" Kicker in a ported box and I pretty much happy with it. Don't know your goals in low-frequency department, but I guess your double 12"s would easily satisfy you.